(1) Many prescription medications, including digitalis, phenothiazine , theophylline, and beta agonists, can cause palpitations.(2) Medications with antihistamine properties, such as anticholinergic agents, phenothiazine , and tricyclic antidepressants, also should be discontinued before skin testing.(3) The systemic use of phenothiazines , a class of neuroleptic drugs used in the therapy of mental disorders, such as schizophrenia, organic psychoses and other mental disorders, is known to induce photosensitization of the skin.(4) The finding that phenothiazines reduce the incidence of cancer in humans generated a broad range of experimental studies, which confirmed their antitumor, cancer-chemopreventive and antimutagenic activities.(5) However, the data presented suggest that some photosensitizing effect in humans is possible, although lower than that exerted by other drugs such as quinolone antibiotics, anti-inflammatory drugs or phenothiazines .
